Medical researchers are making great strides in the development of Induced Pluripotent Stem Cells (iPS Cells). Will they soon be able to use them to repair or even replace diseased organs in our bodies?

 Every human being, indeed every animal begins its life as a fertilized egg cell that begins to divide and grow into many cells. As more and more cells are generated they begin to grow into certain types of cells, heart cells, stomach cells, muscle cells, brain cells, over 200 kinds of specialized cells making up every organ in the body. Those early cells, the cells generated before specialization into organ cells sets in are given the name embryonic stem cells or sometimes just stem cells.

Male sperm cells surround a female egg cell trying to get inside. Once one of them succeeds the egg will be fertilized and will develop into a fetus. (Credit: Pinterest)
After fertilization the egg cell begins to divide to form a blastocyst. At this stage the cells are all embryonic stem cells. (Credit: Assisted Fertility Program)

Research into the properties of these undifferentiated stem cells began back in the 1960s at the University of Toronto by biologists Ernest McCulloch and James Till. However it wasn’t until 1981 that British biologists Martin Evans and Matthew Kaufman succeeded in isolating and culturing embryonic stem cells from mice. This advance enabled researchers to begin experimenting with stem cells, to alter or delete some of the genes in the cells in order to investigate the processes that turned them into the specialized cells.

Stem cell pioneers Ernst McCulloch (l) and James Till (r). (Credit: University of Toronto Magazine)

Since stem cells are capable of becoming any type of cell in the body, a property technically referred to as pluripotent, the possibility that they could be used to help repair, perhaps even replace damaged organs has been the driving force in stem cell research. The adult body has few stem cells remaining however, only in the bone marrow or gonads, and those stem cells are only capable of turning into a few types of cells, either blood cells or sex cells.

This is the reason why stem cell researchers were so anxious to obtain embryonic stem cells in order to understand the processes that changed a stem cell into a particular type of body cell. From the 1980s through the early 2000s many biologists conducted an enormous amount of work using embryonic stem cells obtained from animal, primarily mouse fetuses. Unfortunately the only supply of human embryonic stem cells was from the fetuses of women who had undergone surgical abortions, a source that brought with it a tremendous amount of controversy. Because of stem cell research’s association with the practice of abortion even scientists who worked with animal stem cells had difficulties in obtaining funding and the entire field of stem cell research in the U.S. suffered as a result.

A human embryo at four weeks after fertilization, a time when many abortions are performed. At this stage there are millions of embryonic stem cells remaining. (Credit: Abort73.com)

At the same time the researchers all knew that in order to really fulfill the promise of stem cells it was going to be necessary for them to find a method to reverse the process, to take differentiated body cells, say blood cells or muscle cells, and turn them back into embryonic stem cells. After all, think about it, if you had a heart problem and doctors tried to use the stem cells from an aborted fetus to repair your heart wouldn’t your immune system reject those stem cells just as it would try to reject a heart transplant. But if your own adult cells could be turned back into stem cells and then those stem cells used to repair diseased heart tissue there would be no problem of rejection.

  The breakthrough came in 2006 when a Japanese team led by Shinya Yamanaka succeeded in converting adult fibroblast cells into pluripotent stem cells by modifying only four genes. These converted cells were given the name Induced Pluripotent Stem Cells or iPS Cells and Shinya Yamanaka was awarded the 2012 Nobel Prize in medicine for his achievement.

Discoverer of iPS cells Shinya Yamanaka at work in his Labouratory. (Credit: UCSF)

With the development of iPS cells biologists could now take the adult cells of any individual, convert them into stem cells and culture them into as many stem cells as needed. The focus of stem cell research now shifted from the study of stem cells themselves to learning how to use stem cells to help patients with damaged or diseased organs, a field of research that has become known as ‘regenerative medicine’.

Converting adult Fibroblast cells back into stem cells (iPS Cells) allows many different kinds of cells to be regenerated in the lab. (Credit: R&D Systems)

At present there are several distinct lines of ongoing research. The ‘Holy Grail’ of regenerative medicine would be the ‘manufacture’ of entire organs that could replace damaged ones. For example, for a patient suffering from a diseased kidney, instead of getting a kidney transplant from a donor, which would carry with it the problem of organ rejection, cells from the patient’s own body would be converted into iPS cells. Those iPS cells would then be induced to generate a brand new kidney, that patient’s kidney since their cells were used. That new kidney could then be transplanted into the patient’s body without any fear of rejection.

The promise of Regenerative Medicine, using stem cells to grow brand new organs to replace damaged or worn out ones! (Credit: DL3 Spa Services)

Working towards that long range goal the biologists have been moving forward with the idea of repairing rather than replacing damaged organs. In an ongoing study being conducted at Osaka University in Japan by Professor Yoshiki Sawa blood cells were taken from test animals and converted into iPS cells. The iPS cells were then induced into becoming heart muscle cells that were then grown into a sheet of heart muscle tissue that beated, just like a normal heart. The sheet of heart muscle was then surgically placed onto the test animal’s heart, strengthening it and increasing heart function.

Sheet of heart muscle tissue manufactured from iPS Cells. (Credit: NHK)

Over a hundred such experimental surgeries were performed first on animals in order to refine the technique and make certain that everything possible was done to maintain safety before any human trials were attempted. It wasn’t until the 27th of January of 2020 that the first surgery was performed to insert a 4cm circular section of manufactured heart tissue on to a damaged area of a human patient’s heart. That patient is recovering and being constantly monitored to determine how much improvement in heart function the new heart tissue is providing, and for how long. Nevertheless this clinical trial gives a little glimpse into the potential of iPS Cells.

Heart surgery performed for first time on 27 January 2020. Sheet of heart muscle tissue employed to strengthen patient’s weakened heart. (Credit: www.asahi.com)

Another possible use of iPS cells would be to greatly increase the blood available for operations and other medical practices. Blood banks are chronically short on precious blood plasma so the possibility that that iPS cells could be grown in large quantities and then turned into blood cells is very attractive.

The use of iPS stem cells is not without its problems however. First of all at present the efficiency of converting adult cells into iPS cells is less than 1% making the process both slow and expensive. Another major difficulty is the tendency of iPS cells to form cancerous tumors, a danger that has severely limited the number of human experiments using iPS cells.

One serious problem with iPS Cells is that they can lead to the formation of cancerous tumors. (Credit: Irish Times)

 Despite these difficulties advances in the use of iPS cells in the field of regenerative medicine is accelerating. Who knows what new medical procedures will be developed in the next 10 to 20 years using iPS cells.

Paleontology News for May 2020. What’s there to do when you’re ordered to stay at home during a pandemic? Why study dinosaurs of course!

We tend to think of paleontologists as working out in the field, digging around in some barren, rocky terrain unearthing the remains of long extinct forms of life. That’s partly true of course, after all you have to find some fossils before you can study them. And most paleontologists do prefer being on site where the discoveries are made, never knowing what they’ll see in the very next rock they turn over.

Although it is often hard, dirty, sweaty work take it from me fossil hunting is the pure joy of discovery. (Credit: CBS Denver)

Still, a lot of the work in studying ancient life can only be accomplished back in the lab or in the office. Cleaning fossils, examining fossils, comparing them to similar fossils and of course, writing up the papers that will tell your colleagues, and interested laymen like me, what you’ve found. A lot of that work can safely be accomplished even during the ‘social distancing’ needed to stop the spread of Covid-19. So let’s take a look at some of the work that’s being accomplished by paleontologists even in the shadow of a deadly disease.

Cleaning fossils has to be done in the lab where you can take your time and do a meticulous thorough job. (Credit: Wikimedia Commons)

Spinosaurus aegyptiacus is one of the most intriguing dinosaur species known to science. Originally discovered in Egypt back in 1912, Spinosaurus is a large predatory dinosaur belonging to the group known as theropods, the group that includes the mighty T rex and Allosaurus along with the smaller Raptors. Spinosaurus lived during the middle to late Cretaceous period (112 to 93 million years ago) and had one distinguishing feature that set it apart from its relatives, a broad, sail like flap of skin along its back that was held up by spines coming off of the animal’s vertebra. See image below. Large, floppy skin features like Spinosaurus’ sail are usually either for thermal regulation or display or both.

Artist’s impression of a Spinosaurus with a human figure to give scale. (Credit: New York Times)

The loss of the only known skeleton of Spinosaurus during World War 2 brought all research into the creature to a halt, and Spinosaurus was almost forgotten by science. Then in the 1990s further fossils belonging to another species of Spinosaurus, S maroccanus were discovered in Morocco by a National Geographic team led by Doctor Nizar Ibrahim of the University of Detroit Mercy along with Professor Paul Sereno of the University of Chicago. Exploring a layer of rock that has been named the Kem Kem group and which is exposed across a wide area of Morocco the team has unearthed fossils of many different species including specimens of Spinosaurus that have allowed paleontologists to resume the study of this odd dinosaur.

University of Chicago paleontologist Paul Sereno with a skeleton of Spinosaurus. (Credit: The Telegraph)

Actually there is a lot of disagreement over whether S maroccanus is a second species. With the original S aegyptiacus destroyed it is impossible to make a direct comparison and the drawings that remain of the bones of S aegyptiacus are insufficient to determine just how different the new specimens are with certainty.

The new specimens have re-ignited several debates about the nature of Spinosaurus, these include whether or not the predator was actually larger than the famous T rex and whether or not Spinosaurus was at least semi-aquatic, spending a large fraction of its life in the water. Based on the examination of the fossils discovered during the 1990s the full length of Spinosaurus was between 12.5 and 18 meters while the animal’s weight was between 6.5 and 7.5 tonnes. If these estimates are true that would in fact make Spinosaurus a fraction larger than the venerable T rex.

As to the question of Spinosaurus being semi-aquatic the dinosaur’s long narrow, crocodile like snout along with its short, powerful legs do indicate a life style similar to that of…well crocodiles. Add in the fact that the fossils of Spinosaurus were discovered in the same rock beds that yielded numerous specimens of an ancient and extinct sawfish named Onchopristis and it seems clear that Spinosaurus lived in an environment that was as much water as land, such as a swampy river delta.

The extinct fish Onchopristis. Measuring eight meters in maximum length this creature was a monster itself! (Credit: Prehistoric Life -Wiki)
Artist’s impression of the sort of environment and life that Spinosaurus lived. (Credit: BBC)

Now perhaps the crucial piece of evidence has been unearthed, as bones from the tail of Spinosaurus have recently been discovered. Based on those bones the tail of Spinosaurus was a long, flexible and fin like. A tail well suited to providing propulsion in the water. This latest discovery pretty much clinches the hypothesis that Spinosaurus is the first type of dinosaur known to have evolved into a swimming creature.

Tail bones tell the story. The tail of Spinosaurus was big and powerful, perfect for propulsion underwater! (Sci-news.com)

These new discoveries make Spinosaurus an example of how varied and diverse the group we call dinosaurs was, and the research published by Ibrahim and Sereno provides an example of how scientists can continue their work even during a pandemic.

Space news for May 2020.

The big event in space this month will undoubtedly be the launch of the first manned mission for Space X’s Dragon capsule. This launch, to take place from NASA’s Kennedy Space Center in Florida, will not only represent the first ever manned space mission to be conducted by a commercial company but will also mark the return of manned space operations to American soil. Ever since the last flight of the space shuttle Atlantis launched on 8 July 2011 American astronauts have been dependent on purchased tickets aboard the Russian Soyuz spacecraft in order to get to the International Space Station (ISS) at a cost of as much as $80 million per seat.

Landing of shuttle Atlantis marking the end of NASA’s Space Shuttle program in July of 2011. Since this mission American astronauts have been dependent on the Russian’s to get into space. (Credit: NASA)

That dependence is scheduled to end on May the 27th with lift off at 4:32 PM EDT, although weather or technical problems could certainly lead to a delay. The two-man crew for this first manned mission, officially referred to as Demo-2, consists of veteran space shuttle astronauts Doug Hurley and Bob Behnken. Once in orbit Hurley and Behnken will pilot their Dragon capsule toward a docking with the ISS approximately 24hrs after launch.

NASA Astronauts Doug Hurley (foreground) and Bob Behnken (background) in training on a Space X Dragon Capsule simulator. (Credit: Geekwire)

How long Hurley and Behnken will remain at the ISS has yet to be decided. The original mission plan was for a stay of only a week but NASA is anxious to phase out using the Russian Soyuz to man the ISS so Hurley and Behnken’s mission has now been extended to at least a month and could last as long as 110 days. NASA intends to decide just how long the mission will last once the crew is aboard the ISS.

The goal of Space X’s mission, and NASA’s Commercial Crew Program is to deliver astronauts to the International Space Station (ISS) (Credit: Wikipedia)

Presently the American section of the ISS is being manned solely by NASA astronaut Chris Cassidy so there is plenty of standard maintenance and upkeep work to keep Behnken and Hurley occupied. There’s one job in particular that Chris Cassidy cannot do alone because it requires a spacewalk and NASA insists for safety’s sake that all spacewalks be conduced by at least two astronauts. The job consists of swapping out the station’s batteries. Of the two Space X crewmen Bob Behnken is the one with EVA experience so he has spend the last few months getting in some extra training, learning his way around the outside of the station.

Like any home the ISS requires occasional outdoor maintenance. However an EVA requires a bit more planning and skill than mowing your lawn. (Credit: Spaceflight101)

 This first mission in NASA’s commercial crew program has been a long time in coming. Space X and its competitor Boeing were initially funded back in 2014 with a goal of a first mission in 2017 but numerous difficulties and testing setbacks have led to several years of delay.

In fact Boeing’s Starliner capsule is still not ready for its first manned launch. The spacecraft underwent what was hoped to be its final unmanned test flight back in December of 2019 but a series of software problems occurred during the mission, the capsule was unable to reach the ISS and had to be brought back to Earth early. Boeing is still in the midst of debugging the Starliner’s software and hopes to conduct a second unmanned mission later this fall. If that test flight is successful the Starliner’s first manned flight could take place early next year.

The launch of Boeing’s Starliner capsule on its unmanned orbital test flight in December 2019. Although the capsule’s hardware all worked as required there were a number of problems with the spacecraft’s software. (Credit: Business Insider)

Of course everything that happens these days takes place in the shadow of Covid-19 and the launch of Space X’s Dragon capsule is no exception. NASA personnel at Cape Kennedy have worked very hard to keep all activities dealing with the ISS active and fully staffed. That means that the May27 launch has been given high priority and the space agency is determined to carry out the Dragon mission as soon as the equipment and weather are ready.

Some NASA programs, like the James Webb Space Telescope shown here, have been delayed because of the Covid-19 pandemic. However NASA is marshaling all its resources to lauch the Space X Dragon capsule on schedule. (Credit: Spacenews)

However, unlike every American manned space mission since Alan Shepard in 1961 the Space X launch will take place without a crowd of visitors and VIPs to watch. In order to prevent the spread of the virus only a few reporters will be permitted to attend the takeoff. Of course crowds may gather along the nearby public beaches but personally I’ll be quite happy just watching the show on my computer.

Former President Lyndon Johnson watches the launch of Apollo 11. There will be no such crowd gathered to watch the launch of Space X’s first manned mission. (Credit: National Geographic)

Surprisingly enough there is some other space news happening and part of it concerns the Russian Soyuz spacecraft and Covid-19. Because of the spread of the disease in Russia that country’s space agency Roscosmos has temporarily discontinued production of the Soyuz launch vehicles. Not to worry however as there are currently 52 Soyuz rockets in storage ready for use so there’s little chance in the near future of a mission being delayed or cancelled because of the lack of a launch vehicle.

Due to the Covid-19 outbreak Russia has temporarily halted manufacture of it’s Soyuz launch system. (Credit: Russia Space Web)

Finally, even while we here on Earth are struggling with Covid-19 our robotic space probes throughout the Solar system are still busy exploring distant worlds. That includes the OSIRIS-REx mission to the asteroid Bennu. OSIRIS-REx has been orbiting the asteroid since 2018 and is scheduled to swoop down to the asteroid’s surface in order to grab a sample of Bennu in August. On April 14th the spacecraft conducted a practice run, coming within 75 meters of the asteroid before returning to its normal orbital distance of 1 kilometer.

NASA is conducting the final practice runs of the OSIRIS-REx spaceprobe’s attemp to gather samples of the asteroid Bennu. (Credit: SpaceNews Magazine)

Once OSIRIS-REx has completed is sample acquisition procedure it will begin its 2.5 year journey back to Earth in March2021. That means that by September of 2023 NASA will have samples of yet another body in our Solar system.

Progress, even as we deal with a pandemic.

A star orbiting the black hole at the center of our galaxy provides direct observational evidence that Einstein’s theory of gravity is more accurate than Newton’s.

One of the basic laws of physics that students learn in high school is that the planets orbit around the Sun not in perfect circles by rather in the flattened circles formally known as ellipses, see image below. This idea of orbits being ellipses is Johannes Kepler’s first law of planetary motion.

Kepler’s first law is a direct consequence of Newton’s law of Gravity, but the gravity of a third body, not shown here, will cause the ellipse to wobble! (Credit: Quora)

A few decades after Kepler Sir Isaac Newton showed that it was the gravitational pull of the Sun that pulled the planets into those elliptical orbits. However, an orbit is only a precise ellipse if there is just a star and one planet. In our Solar system the other planets have their own gravitational pulls as well, although they are not nearly as strong as the Sun’s. Nevertheless because of the planets all pulling on each other those elliptical orbits aren’t exact, they all wobble around a bit.

In our Solar System the Planet Jupiter weighs as much as all the other planets combined so it causes most of the wobble in the other planet’s orbits! (Credit: Hubble Space Telescope)

In fact after the planet Uranus was discovered astronomers found that its orbit had a wobble in it that couldn’t be explained by the gravitational pulls of the then known planets. In the year 1821 it was suggested that another planet, further out than Uranus could be the culprit and after a lot of math, more than 20 years of calculations by hand, the planet Neptune was discovered in 1846 right where Newton’s gravity said it would be.

It was a wobble in the orbit of Uranus (l) that enabled astronomers to find Neptune (r). (Credit: Daily Mail)

Just a few years later, 1859 to be exact, a peculiar kind of wobble, known as the precession of perihelion, was found in the orbit of Mercury. Now perihelion is the closest point to the Sun in the orbit of a planet and a precession would mean a shifting of where, relative to the Sun, perihelion occurs. See image below.

The precession of perihelion could not be explained by the pull of the other known planets. Was there another planet even closer to the Sun? (Credit: Independent BD)

By the way, this shift measured by the astronomers was tiny, amounting to only 43 seconds of arc per century. If you recall that a complete circle has 360 degrees and each degree is made up of 60 minutes and each minute has 60 seconds then you can see that a change of 43 seconds in a century is very small indeed.

Once again it was suggested that another planet, one even closer to the Sun than Mercury, was the cause of the precession. After their success with Neptune the astronomers were so certain that they gave this ‘new planet’ the name Vulcan before they even found it. In fact they never found it, despite searching for more than 30 years.

In ‘Star Trek’ Mister Spock’s home world Vulcan was named for the hypothetical planet inside the orbit of Mercury! (Credit: Pinterest)

It was Einstein who finally figured out what was going on. In his General Theory of Relativity in 1915 the physicist described gravity not as a force that passed between two massive bodies but rather as a bending of space-time itself. This bending of space-time causes the motion of objects to deflect from a straight line and if the bending is enough, if gravity is strong enough, the ‘straightest path’ for an object can be a closed elliptical orbit.

In Einstein’s General Theory of Relativity the mass of an object bends Space-Time itself caused the path of other objects to bend, even into an orbit! (Credit: Extreme Tech)

For a weak gravitational field the difference between Newton and Einstein is extremely small. So small that when NASA sends a space probe to another planet it uses Newton’s equations not Einstein’s. The math needed with Newton is just so much easier, trust me.

Einstein’s equation for the gravitational field. This is actually shorthand for a system of 16 equations all of which must be solved simultaneously! (Credit: WordPress.com)

As the strength of gravity grows however the difference between the two theories grows exponentially. That’s why Einstein’s theory predicts the existence of black holes, objects with gravity so strong that nothing can escape them, while Newton’s theory doesn’t. And if you get close enough to our Sun, say where Mercury is, the difference becomes large enough to be measured, it works out to be 43 seconds of arc per century. When Einstein solved his field equations the solution to Mercury’s precession just popped right out. This was in fact the first evidence that Einstein’s theory was correct.

Now astronomers with the European Southern Observatory’s (ESO’s) Very Large telescope (VLT), located in the Atacama Desert in Chile have found another example of precession as predicted by Einstein. For the past 27 years the team have been studying a star called S2 as it orbits around the supermassive black hole Sagittarius A* in the very center of our galaxy.

The center of out Glalxy lies between the constellations of Sagittarius and Scorpio. Try to find it some clear night this summer! (Credit: EarthSky)
At the center of all large galaxies lies a supermassive black hole. Our galaxy’s is called Sagittarius A. (Credit: Daily Mail)

S2 completes an orbit around Sagittarius A* once every 16 years and at its closest point the star comes closer than 20 billion kilometers to the black hole, a distance that is about 120 times that between our Earth and the Sun. At that closet point S2 has to move at 3% of the speed of light in order to not be swallowed by Sagittarius A*. Just imagine that, an object as big and massive as a star moving at 3% the speed of light!

Artist’s impression of the star S2 at it’s closest approach to the supermassive black hole Sagittarius A. (Credit: Wikipedia)

Analyzing their data the astronomers, led by Reinhard Genzel, Director at the Max Planck Institute for Extraterrestrial Physics, have now published their results in an article in the journal Astronomy and Astrophysics. What the astronomers have found confirms Einstein’s theory once again. Even at a distance of 26,000 light years they were able to measure the precession of S2’s orbit around Sagittarius A* and it matches up with Einstein’s theory nicely. In fact their results have allowed them to make the most precise measurement yet of the mass of the black hole itself, 4 million times the mass of our Sun.

Because of the precession calculated from Einstein’s theory, S2’s orbit around the black hole will make a lovely Rosetta shape. (Credit: Syfy)

Future observations of S2 and the region around Sagittarius A* will be even more precise and detailed once construction is completed on the ESO’s new Extremely Large Telescope (ELT) in 2025. The astronomers hope to find fainter stars that come even closer to Sagittarius A*, perhaps even close enough to feel the dragging of space-time caused by the spin of the black hole. That’s another prediction of Einstein’s theory that has yet to be observed anywhere. That would be further proof that General Relativity is the most accurate theory for space-time outside of a black hole.

But as for what goes on inside a black hole? That’s going to have to wait for the physics of the future.

What is Soap?

In this era of Covid-19 we hear one piece of advice dozens of times everyday, ‘Wash Your Hands’, ‘Work up a good lather of Soap and Warm Water and Wash your Hands while singing Happy Birthday Twice!’ Which begs the question, what is Soap? Why is Soap so central to both cleanliness and good hygiene?

Just a little friendly advice!

Chemically soaps are a class of compounds known as salts of fatty acids and are produced by combining fats or oils with an alkaline base in solution under heat, a process technically known as Saponification. Soaps include a wide range of substances used for a variety of purposes from thickening agent to lubrication but the most familiar use of soap is undoubtedly as a cleaning agent and in this post I will mainly be referring to these types of soaps.

The Chemical reaction that produces soap, call saponificaction. (Credit: Thought Company)

Toilet soaps as they are known are produced by using either Sodium Hydroxide (NaOH) or Potassium Hydroxide (KOH) as the alkaline. When sodium hydroxide is combined with a thick fat such as lard or tallow the result will be a hard soap while potassium hydroxide and a light oil, such as olive oil, will produce a softer or even a liquid soap. When Lithium Hydroxide is used as the alkaline the result is lithium stearate a common industrial lubricant.

Making soap is actually pretty easy, many people do it as a hobby. (Credit: The Spruce Crafts)

So how do soaps perform their job as a cleaning agent? Well, remember that oil and water don’t mix because oils are non-polar molecules while water is a polar molecule. However a soap molecule is a combination of an alkaline and fat. That arrangement produces a molecule that is polar at one end, attracted to water, but non-polar at the other end, attracted to fats and oils.  

Basic layout of a soap molecule. One end can dissolve in water while the other end can dissolve in fats or oils! (Credit: Nature on the Shelf)

Because of that when used in combination with water soap acts as a surfactant, a material that breaks the surface tension of water allowing the water to more easily dissolve dirt and grime, along with such polar molecules as proteins and sugars, so that they can be washed away.

Soap’s greatest trick however is its ability to encase droplets of oil or fat in tiny spheres of soap molecules called micelles. Unlike oils and fats that do not dissolve in water, these micelles do dissolve allowing the oils and fats to be washed away with the dirt and grime. In other words not only does soap help water to better dissolve the substances it usually can, it also enables water to dissolve substances it generally can’t.

Molecules of soap form ‘Micelles’ around fats and oils allowing them to be dissolved in water and washed away! (Credit: Quora)

This also makes soap an effective anti-biotic because the harsh alkaline at one end of the soap molecule can break up the protein shells that protect viruses. At the same time the micelles can absorb the fats in the cell walls of bacteria, killing them. Of course modern, manufactured soaps often have various chemicals added to them in order to make them even more ‘anti-bacterial’ but it is worth remembering that any soap can be used as a disinfectant.

Soap by itself can help protect you from germs but modern soaps often have other chemicals added to make them true disinfectants. (Credit: Medium)

Archaeological evidence for the manufacture of soap dates all the way back to ancient Babylon with a cuneiform tablet dated to 2200 BCE that describes the earliest known recipe for soap making. The Egyptians, Greeks and Hebrews all had their own varieties of soaps, mostly produced with olive oil and potash, an alkaline solution made from the ashes of a fire, along with a bit of quicklime. This method of soap making produced a strong and particularly harsh soap.

Babylonian table with a recipe for making soap! (Credit: KU Chemistry)
Egyptian ladies washing themselves with soap! (Credit: Realm of History)

Surprisingly the Romans, who are well known for their baths, did not care very much for soap. They preferred to clean their bodies by rubbing them with olive oil and then scrapping the oil off with a dull knife called a strigil. They considered the harsh types of soaps made in the eastern Mediterranean as harmful for the skin. Only after becoming familiar with the milder soaps of the Celts and Germans did the Romans start using soap. (Imagine that, the fierce northern barbarians had the gentler soap!)

A Roman bronze Strigil used to scrap oil off of the body in a Roman bath. I think I’ll stick with soap and water! (Credit: Christie’s)

Both medieval Europe and the Islamic world had soaps but these soaps were generally harsh with an unpleasant smell and so expensive that only the very rich could afford to bathe frequently. Large-scale manufacture of soaps only began in the late 18th century and coincided with a campaign that linked daily washing with good hygiene, ‘cleanliness is next to Godliness!’

In the 19th Century Cleanliness, Hygiene and Morality were pretty much equated. (Credit: Alamy)

Today of course there is a tremendous variety of different kinds of soap available in your local supermarket. There are soaps that can remove the toughest dirt and grime, soaps that actually soften the skin and even soaps that are 9944/100 % pure soap. There are solid bar soaps and liquid soaps, advertised as ‘body wash’, there are even powered soaps. Whatever kind of soap you prefer we all know that regularly washing your hands with soap and warm water is our first line of defense against Covid-19. So wash up and remember, ‘I’m pulling for ya, we’re all in this together’! 

NASA continues development effort on Ion rockets, are they the future of Space Exploration?

For over 60 years now rockets using highly combustible chemicals have dominated space exploration. Starting with the launch of Sputnik 1 on the USSR’s R-7 rocket to the latest Space X Falcon 9 reusable rocket virtually every rocket used to get into space or to travel to other planets has been a chemical rocket.

The liftoff of Apollo 11 on its way to the first Lunar landing. A rocket launch is an icon of our age with all of the smoke and flames produced by a chemical reaction. (Credit: Amazon.com)

That’s one of the reasons why human beings haven’t gone any further than the Moon and even our robotic probes take years to get to the other planets. You see chemical fuels simply aren’t very powerful; to be specific the exhaust velocities possible with chemical fuels are completely inadequate if you want to achieve the velocities needed for space travel.

Two ways to provide thrust to a rocket. Chemical reactions can only supply a small speed and therefore require an enormous amount of fuel. (Credit: qrg.northwestern.edu)

Let’s first consider a few facts. First, the velocity needed to just get into Earth orbit, is 7.9 kilometers per second while the absolute best known exhaust velocity for a chemical reaction, which is oxygen and hydrogen, is only about 4.5 kilometers per second.

The low exhaust velocities possible with chemical fuels are the reason that most rockets are little more than big bags of fuel and most space launch systems use a multistage approach to getting into space, throwing away 90% of the rocket, along with burning all that fuel, just to get a small payload into space!

In order to get the tiny Apollo Command Module, along with the astronauts, to the Moon and back it was necessary to throw away the entire rest of the massive Saturn V rocket in stages! (Credit: Kids News)

Rocket engineers have known about this problem since before the beginning of the space age. They also knew that in order to achieve the very highest exhaust velocities some form of electric propulsion, more commonly called Ion propulsion, would be needed.

NASA’s new X3 Ion Thruster developed by the University of Michigan with NASA’s assistance. It may look a lot gentler than a chemical rocket but the exhaust velocity is ten times greater and this engine can fire for months or even years! (Credit: Science Alert)

The main principles behind ion rockets are pretty simple. You take a normal, electrically neutral atom and strip off one or more of its electrons by means of an electric discharge. This leaves the atom as a positively charged ion. This ion can then be accelerated to very a very high velocity by placing it in a voltage field, the ion will be repelled by the positive voltage and attracted by the negative voltage, opposites attract after all. Once the ion has acquired the desired velocity it is directed out the back of your rocket generating a tiny thrust pushing you forward. Obviously the more atoms you fire out the back the greater the thrust generated.

Basic schematic of an Ion rocket engine. It is rather complicated and everything has to be precisely design but after all, this is rocket science. (Credit: Quora)

If this technology reminds you of the particle accelerators / atom smashers that physicists use to experiment with elementary particles you’re not far off. Ion rocket engines are in fact particle accelerators that, instead of smashing atoms into each other, use those accelerated atoms as propellant. Because of this similarity however, the potential exhaust velocity for an ion rocket is literally within a fraction of the speed of light.

In some ways an Ion rocket engine is like a single stage of a Linear Particle Accelerator. Such accelerators can speed up particles to nearly the speed of light. (Credit: Wikipedia)

One problem with ion rocket engines right at the start, those electrons you stripped off of the ions. Well if you don’t somehow get them back on the ions before they are fired out of the back your rocket will quickly build up a huge negative charge that will just screw everything up! Because of this fact ion engines are designed with a final, negatively charged grid or electron gun so that the ions regain their electrons.

A second, rather larger problem is that unlike chemical rockets that produce an enormous amount of thrust for a few minutes, the Saturn V produced over 34 million Newtons of thrust, an ion rocket produces only a tiny amount of thrust, but they can continue to do so for years, eventually producing a far greater total push. The reason for this difference is that the electric power needed to ionize and then accelerate the propellant’s atoms is so large that only a tiny amount of fuel can be consumed per second.

This low thrust makes ion rockets unsuitable for lunching from Earth’s surface, since you need to have enough thrust to overcome a rocket’s weight before it will even start to move. However it makes them excellent choices for robotic missions to other planets and several such ion powered missions have already flown.

The first demonstration of an ion rocket engine in Earth orbit took place on the Space Electric Rocket Test (SERT 2) launched in February of 1970. The two ion engines on board only produced 0.027N of thrust each but they managed to achieve a propellant exhaust velocity of more than 22 kilometers per second, nearly five times that of the best chemical fuels. The SERT 2 test vehicle also demonstrated the ability of ion rockets to work for long periods of time as one engine fired continuously for five months and the second for three before electrical problems caused them to fail.

The first test of ion rockets in space was NASA’s SERT 2 mission. The thrust provided by the ion engines was tiny but they fired for a combined total of 8 months. (Credit: Gunter’s Space Page)

The most successful use of ion rockets to date is probably NASA’s Dawn mission. Dawn was the first man made object to orbit two astronomical objects other than the Earth, the dwarf planet Ceres and the asteroid Vega. This space age first was only possible because of Dawn’s ion propulsion engine, which only provided a thrust of 90 mN but which operated throughout the mission, a total of 5.9 years. Just imagine a rocket engine firing for 5.9 years!

The Dawn robotic space probe firing its ion engine as it approaches its first objective the asteroid Vega. (Credit: Pressfrom.info)

NASA’s future plans include increasing use of ion rockets for interplanetary missions. To that end it has been funding the Advanced Electric Propulsion System (AEPS) a 50 kW ion rocket that is currently under development at the Glenn Research Center and Aerojet Rocketdyne. The design goals of this program include a nominal thrust of 1.77N for a full life of 50,000 hours, that’s 5.7 years! Testing is now underway with a possible first mission on NASA’s Deep Space Gateway in Lunar Orbit. (See my posts of 24 March 2018 and 29 May 2019 for more information about the Deep Space Gateway) Despite all of this progress it could be a considerable amount of time before ion engines are used to propel a manned mission to another planet. Nevertheless the enormous advantages inherent in the almost limitless exhaust velocity ion engines provide all but assures that they will be playing an important role in humanity’s future exploration of the Solar system.

Plant Intelligence. Wait; there is such a thing?

We humans like to think of ourselves as being special, not just more intelligent than ‘the animals’, but a higher sort of intelligence. In fact we used to insist that anytime an animal showed something resembling conscious thought we’d say that it was really just behaving by ‘instinct’, not intelligence.

I don’t know this Will Cuppy but I think I’m going to have to check him out! (Credit: AZ Quotes)

That way of thinking has been pretty much tossed into the dustbin of science as naturalists have studied the many different species of animals who use tools, those who can communicate in some pretty sophisticated ways and whose problem solving skills can almost seem to rival ours in some ways. The list of these, intelligent species is quite long and getting longer everyday. Not just dolphins and chimpanzees but also dogs, elephants and squirrels not to mention other animals like ravens, parrots and even octopi. So let’s be honest, animals in general can be quite intelligent, each in their own way!

Many species of animals have been observed to use tools but only Humans and our cousins the Chimpanzees are known to use more than one tool. (Credit: Britannica)

At least it’s only animals that show intelligence right? Plants don’t have anything like a brain. In fact plants don’t even move unless the wind blows on their leaves so how could you even tell if plants had anything like intelligence.

Not quite like that! (Credit: R. A. Lawler)

Actually of course plants do move, a sunflower will follow Sun across the sky each day and if you’ve ever had to keep ivy from twisting its way up a wall or tree trunk you’d know that plants can grow in a manner that displays a great deal of purpose if not intelligence. There is in fact growing evidence that plants are aware of their environment and can react to stimuli in ways that can be described as intelligent.

Take the Venus flytrap for example. Each individual trap has two hair like sensors that ‘tell’ the plant when something is in the trap. However in order to keep the trap from closing on a piece of a leaf or dirt it’s only when an insect triggers both hair sensors that the trap snaps shut. That’s certainly more awareness and intelligence than plants are generally given credit for.

Venus Flytraps live in soil so infertile that they have evolved to supplement their diet by eating the insects they catch! (Credit: New Scientist)

Now consider a few experiments that have been conducted by Doctor Katja Tielbörger of the University of Tübingen in Germany. Working with the plant Creepy Cinquefoil (Potentilla reptans) Dr. Tielbörger used strips of green coloured cellophane to simulate competing plants. In one setup the competing plants were low vegetation that surrounded the Cinquefoil test plant. The Cinquefoil responded by shooting upward in order to get above the competition. In a second test the competing plant was very tall, hanging over the Cinquefoil. The Cinquefoil responded by growing outward to get away from its competition. Finally, the competing plants completely encased the Cinquefoil so that only bits and pieces of light could get through. The Cinquefoil responded by staying small but growing large leaves in order to catch every bit of light possible.

Part of the test setup for DR. Tielborger’s experiments on the decision making ability of plants. (Credit: Nature)

If you think that maybe those experiments only demonstrate that plants have evolved mechanisms that allow them to grow towards the light then consider this second experiment that Dr. Tielbörger performed with a different plant, Mimosa pudica, also known as the sensitive plant. M pudica and its relatives are fern plants that are known for their habit of closing up their leaves during the night. M pudica goes a bit further however because it will also close up its leaves when they are grabbed or even roughly brushed against. This behavior makes M pudica an excellent test subject for experiments in plant reaction to stimuli.

The experiment that Dr. Tielbörger conducted was this; whenever she turned on a bright light near an M pudica plant she would then puncture several of the plant’s leaves with a sharp poker. This damage caused the rest of the plant’s leaves to immediately close up. Doing this continuously for a month Dr. Tielbörger then discovered that the plant’s leaves began to close up as soon as she turned on the light and before she began to injure the leaves. The plant had learned to associate the light with the damage caused by the punctures and reacted in a fashion that can only be considered ‘learned’.

Dr. Tielborger poking the leaves of a Mimosa pudica plant in her experiment on plant learning. (Credit: VolkswagenStiftung)

But how can plants learn anything, they don’t have anything like a brain. They don’t even have any kind of a nervous system that would allow them to react to stimuli the way an animal would. Well now a study from the Massachusetts Institute of Technology (MIT) has uncovered one mechanism by which plants may be able to communicate different kinds and different levels of stress throughout their bodies.

Biochemists have known for several years that plant cells use the chemical hydrogen peroxide as a signal to induce production of chemicals known as secondary metabolites that help a cell repair damage to its structure. Some of these chemicals can also produce disagreeable flavours that help the plant to fend off predators. The way in which entire plants use hydrogen peroxide to communicate stress levels between cells has been more elusive however.

Gardeners have known for a long time about the healing effect a little hydrogen peroxide has on plants. (Credit: YouTube)

In a paper in the journal Nature Plants senior author Michael Strano, Professor of Chemical Engineering at MIT, has detailed how he and his team succeeded in inserting sensors made of carbon-nanotubes into plant leaves and stems into order to detect and measure the flow of hydrogen peroxide throughout the plant.

So far the chemists have used their technique on eight different plant species including spinach, arugula and strawberry and plan to try it on other species going forward. These new sensors could give biologists their first glimpse into the ‘nervous system’ of plants, which could lead to a better understanding of plant intelligence.

In another of his experiments Dr. Strano has ‘trained’ spinach plants to detect explosives! (Credit: ZME Science)

Simply put, intelligence is nothing more than an awareness of your environment and reacting to it. When you look at it that way intelligence is pretty much just a part of being alive.

The BepiColombo Space probe is on its way to Mercury, this will be only the third mission to the Solar system’s innermost world.

The BepiColombo robotic probe to Mercury is in many ways the most complex space mission yet attempted. For one thing it is actually three spacecraft in one. Two Mercury orbiters, the Mercury Planetary Orbiter (MPO) designed and built by the European Space Agency (ESA) along with the Mercury Magnetospheric Orbiter (MMO) constructed by the Japanese Aerospace Exploration Agency (JAXA). These two scientific missions are stacked together on top of a propulsion module called the Mercury Transfer Module (MTM). Simply organizing a mission combining two probes from two space agencies had to be a challenge.

Artist’s impression of BepiColombo approaching Mercury. (Credit: New Scientist)
Breakout of the separate modules of the BepiColombo space probe. (Credit: YouTube)

Still, that was child’s play when compared to the task of getting BepiColombo to Mercury. Launched on 20 October 2018 the spacecraft will not enter orbit around Mercury until 5 December 2025. During that long voyage BepiColombo will flyby and receive gravity assists from Earth once, Venus twice and Mercury itself six times. The difficulty of getting to the Sun’s closest planet is the big reason why there have been more unmanned missions to distant Saturn, two Voyagers plus Cassini, than to comparatively nearby Mercury, one Mariner along with the Messenger mission.

BepiColombo’s complicated flight path to Mercury. (Credit: SlidePlayer)

That true, although Mercury is actually only about 20% further away from Earth than Mars is, 90 million kilometers versus 75 million. On the other hand Saturn is fully 17 times further from Earth than Mars is. So why have we sent more spacecraft to Saturn than Mercury?

Speed is one big reason. Orbiting so close to the immense gravity of the Sun Mercury has to possess a very high orbital velocity. In fact if you consider the difference in their orbital velocities, delta vee as astronauts put it, Mercury is only a little ‘closer’ to Earth, 18 km/sec, than Saturn is, 20km/sec. And when you’re sending an unmanned robotic probe to an extraterrestrial body the length of time the journey takes doesn’t matter, which makes speed matter more than distance since that requires more fuel.

Another reason that sending a spacecraft to Mercury is difficult is that the nearby Sun’s gravity is so strong, while Mercury’s is rather weak. This makes finding a stable orbit around Mercury rather difficult, especially an orbit that allows you to investigate all of the areas on the planet you want to observe.

Tiny Mercury is so close to the enormous Sun that finding a stable orbit around the planet isn’t easy. (Credit: Forbes)

BepiColombo has just completed the first if it’s flybys, saying a last Goodbye to Earth on the 11th of April, see image below. Later this year in October the probe will make the first of two consecutive flybys of Venus. Hey you known, Venus is big and bright in the evening sky right now so if you go outside on a clear night not long after sundown, BepiColombo will be somewhere between you and that big, bright evening star to the west.

One of the last images of Earth taken by the BepiColombo space probe as it flew by on 11April2020. The spacecraft used Earth’s gravity to give it a push on its way to Venus for its next flyby. (Credit: European Space Agency (ESA))

Once the combined spacecraft finally settles into Mercury orbit the two orbiters / instrument packages will separate and begin their studies of Mercury. The ESA’s MPO orbiter is outfitted with an array of cameras and spectrometers along with a radiometer, a laser altimeter magnetometer and accelerometer for the study of Mercury’s composition as well as compiling a more accurate map of the planet’s surface.

The planet Mercury as photographed by the Messenger space probe. Nice as this image is scientists would like to see a lot more of the details on the planet’s surface. (Credit: The Independent)

Japan’s MMO probe on the other hand carries instruments designed to study Mercury’s extremely thin atmosphere, the planet’s magnetic field and the way in which they both interact with the power of the Solar wind blowing past the planet. The results of these observations could be especially interesting since they will tell us a great deal about how the evolution of both Mercury and nearby Venus were influenced by the power of the Sun.

The Solar Wind has been buffeting the planet for billions of years. How much damage has it caused on Mercury? And how much will it cause on Earth over the next few billion years? (Credit: Scirence / How Stuff Works)

The proposed time frame for the scientific portion of BepiColombo’s mission is for one year after orbital insertion but with the possibility of an additional one-year extension for both orbiters. It’s possible that the success of BepiColombo will not only provide much valuable data about the Sun’s closest planet, but an example of how the space agencies of different nations can work together.

If only the politicians of different nations followed that example.

Some new discoveries that demonstrate that our Stone Age ancestors weren’t the dumb brutes we like to picture them as.

Our Stone Age ancestors, often dismissively referred to as ‘Cave Men’ are usually portrayed in movies and TV as being hardly more intelligent than the animals they hunted, or were hunted by. Little by little however archaeologists are uncovering evidence that Stone Age peoples were capable of flashes of genius in solving the problems they faced despite their lack of resources or tools.

Our Stone Age ancestors certainly had it rough but they still possessed technology way beyond that of any animal they completed with! (Credit: Wikipedia)

Finding food is of course the biggest problem any animal faces and a large part of the success of our species, Homo sapiens is the wide variety of different kinds of food we eat, and that includes seafood. Think about it, what are we, an ape scarcely out of the jungle trees doing eating not only fish but clams and mussels, squid and even whale meat.

We humans enjoy a wide variety of food from the oceans, lakes and rivers. No other primate consumes such an abundance of seafood which begs the question, when did we start? (Credit: Miss Vicki Pressure Cooker)

Over the last several decades anthropologists have even developed the hypothesis that it was learning how to make use of the food resources they found along the coast of West Africa that spurred a small population of Homo erectus to become H sapiens. There has even been speculation that the brain boosting fatty acids in the seafood those H erectus ate might have contributed to the growth of the larger brains of their descendants, that’s us.

Homo erectus is generally considered to be our direct ancestor. Was it learned to live off of seafood that turned them into us? (Credit: Ancient News)

Nice idea, but there’s new evidence coming from the field that is starting to show that other species of humans were also learning how to feast off of the bounty of the sea. I’m talking about our cousins the Neanderthals in Europe as much as 106,000 years ago.

The new evidence comes from a cave site along the southern coast of Portugal at Figueira Brava near the town of Setubal. The interior of the cave has been excavated by a team of archaeologists led by Doctor Joăo Zilhăo from the University of Barcelona in Spain.

The cave complex at Figueira Brava in Portugal. It’s easy to see that any inhabitants would be likely to start eating some of the food right on their doorstep. (Credit: CNN.com)

Those excavations have unearthed the bones and other indigestible remains of the animals that the Neanderthals were eating. Those remains clearly show that the Neanderthals were not only hunting the local land fauna of deer, goats, ancient cattle and even horses but were also catching and consuming large amounts mussels, crabs and such fish as eels and sharks! Even the bones of sea mammals like seals and dolphins were discovered in the garbage piles left by the Neanderthals. In fact Doctor Zilhăo and his team estimate that just about half of the diet of the inhabitants of Figueira Brava was in fact seafood.

Patella vulgata shells, a kind of edible snail from the cave at Figueira Brava. (Credit: CNN)
Cracked crab claws from the cave. (Credit: CNN)

So it seems as if our direct ancestors were not the only humans smart enough to realize the enormous benefits to be gained from dinning off of seafood.

Another recent discovery that also demonstrates the intelligence of Neanderthals is the unearthing of the earliest known piece of string from a site in Abri du Maras in southern France. According to the study co-authored by Marie-Hĕlĕne Moncel, Director of Research of the French Nation Centre for Scientific Research (CNRS) the string fragment is dated to between 41,000 and 52,000 years ago. Composed of fibers from the inner bark of a conifer tree the section measures 6.2mm in length by 0.5mm in maximum width.

Fragment of string that’s over 40,000 years old. (Credit: Phys.org)

The string fragment is more than just a few fibers twisted together however. In fact the fragment consists of three separate twisted cords that have been interwoven together, indicating a considerable level of experience in textile production. But more than that the fragment also indicates a considerable knowledge of available natural resources since the fibers come from the inner part of the bark of a tree that, according to botanists, is best obtained during the spring or early summer.

The discovery of this single strand of cord opens up the possibility that Neanderthals may have made extensive use of textiles, perhaps to manufacture bags, nets, ropes, mats or perhaps even cloth? In any case this, oldest piece of string provides further evidence that Neanderthals were anything but brutish animals. 

Moving a bit forward in time, to about 25,000 years ago we begin to see the first evidence for actual construction projects by human beings. Some of the most interesting sites come the fertile steppes of Russia south east of Moscow. Here Stone Age hunter-gatherers lived off of one of the largest and most dangerous animals ever pursued by humans, woolly mammoths.

There is plenty of evidence that our Stone Age ancestors did in fact hunt the massive and dangerous Wholly Mammoth. (Credit: The Vintage News)

We know that our ancestors hunted those ice age relatives of elephants because they had the curious habit of building circular walls out of the bones of the mammoths they killed. In a paper published in the journal Antiquity a team led by Alexander Dudin of the Kostenki Museum-Preserve describes the latest, and largest of these mammoth bone structures. Unearthed about 500 kilometers south of Moscow at a site known as Kostenki 11, the ring measures more than 12 meters across and was made from the bones of at least 60 of the huge beasts.

The ring of Mammoth bones at Kostenki 11. (Credit: New York Times)

Because the other mammoth bone structures found across Eastern Europe are smaller than the new one at Kostenki scientists had speculated that the circular walls had once possessed roofs and were used as shelters by the people who made them. At 12 meters across however the mammoth bone circle at Kostenki is too large to be easily roofed in, leaving the researchers to think of some other possible usage for the structure.

Whatever purpose the hunter-gatherers may have had when they built the structures like Kostenki the fact that they did so clearly shows that like modern humans they felt the need to adapt their environment to suit their needs by building.

While it’s true that the earliest structures we humans built were probably used as dwelling places there is evidence that by 7000 years ago people were already learning how to build other types of structures as well. Archaeologists in the Czech Republic have recently discovered a well that they assert is the oldest known wooden structure.

In a study co-authored by Jaroslav Peška head of the Archaeological Centre in Olomouc the well is described as being built in a square shape some 80 cm to a side and 140 cm in height. Each corner of the square consisted of a vertical oaken tree trunk that had been grooved on its sides to allow flat wooden planks, also oak, to be inserted between them to make the square’s sides. This degree of woodworking ability particularly impressed the researchers. “The shape of the individual structural elements and tool marks preserved on their surfaces confirm sophisticated carpentry skills,” they wrote.

7,000 year old well unearthed in the Czech Republic. The woodworking skills of the makers are still evident after all these years. (Credit: New Scientist)

The technique that was used by the archaeologists to date their discovery is known as dendrochronology and is based on an analysis of the tree rings in the well’s wood. Over the past 50 years or so the tree rings in the wood found at many different archaeological sites across Eastern Europe, and from many different time periods, have been matched up, one to another in order to create a exact timeline that can now be used to very precisely date the wood unearthed at any ancient site in Eastern Europe. This same technique has also been developed in other areas of Europe and the different areas of North America and has been used to precisely date many archaeological sites. Using dendrochronology Doctor Peška and his colleagues have succeeded in dating the year that the trees were felled to either 5255 or 5256 BCE.

By comparing the tree rings in wood from different sites archaeologists have developed an extremely accurate dating technique called dendrochronology. (Credit: Museum of Ontario Archaeology)

As different as these three archaeological discoveries are, each in its own way demonstrates that, for all of their primitive tools and crude materials our ancestors nevertheless were able to think up clever solutions to the problems they faced in their daily lives. In fact think about it, if they hadn’t been so bright, we’d still be living in caves ourselves wouldn’t we!

What is a Virus?

Seems like right now all anybody can talk about is the Covid-19 coronavirus and its effects on our society. That begs the question, or questions, just what is a virus, how do they differ from other pathogenic organisms such as bacteria and what makes them such deadly diseases? Oh, and one more question, are they even living things?

The new symbol of fear for this generation. A false colour electronmicroscopic image of a coronavirus. The protein structures in red form the ‘corona’ that gives this class of viruses their name. (Credit: Live Science)

In order to answer that last question we need to consider exactly what it means to be a living thing. What characteristics do living creatures exhibit that non-living things do not. Without getting too technical I think we can all agree on five characteristics.

If you think about it, exactly what makes a living thing ‘alive’ is really rather complicated. (Credit: Transformation Coaching Magazine)

One: All living things, whether plant or animal, ingest nutrients.

Second: Living things metabolize those nutrients.

With the energy gained from those nutrients living things:

Three: Grow

Four: Move

Five: And this is perhaps the most distinguishing characteristic of living things, they reproduce, using a part of their metabolism to create copies of themselves.

Probably the most important difference between living and non-living things is the ability of living things to make copies of themselves, to reproduce. (Credit: SlideShare)

So what about viruses? Well first of all viruses do not ingest nutrients of any kind, ever. And without any nutrients viruses simply do not metabolize, at all. Without the material and energy provided by metabolism viruses neither grow nor move very much, we’ll see in a moment about the only kind of motion a virus is capable of.

So what do viruses do? They reproduce, but they can only do so parasitically inside a normal living cell. Basically once a virus is “born” it is little different from a tiny grain of sand or minute crystal, neither growing nor moving by itself.

A few of the many different kinds of Viruses. (Credit: 123RF.com)

However, if a virus ever comes into contact with a living cell within which it is capable of reproduction it will grab that cell like a mousetrap snapping and inject its own genetic material into the cell. That grabbing, snapping and injecting are the only movements that the virus is ever capable of.

Viruses attacking a bacteria. (Credit: PBS)

Once the genetic material is inside the host cell the virus takes over the cell’s life functions and uses the cell’s own metabolism to reproduce hundreds if not thousands of copies of itself. Eventually the host cell bursts apart releasing the new viruses so that they can infect other cells. Viruses are the ultimate parasite having given up all of life’s functions except reproduction and even requiring another life form to do that. Because of this many microbiologists regard viruses as “organisms at the edge of life” rather than true living things. By the way, since viruses do reproduce they are still able to evolve, just like a living thing!

Viruses can only reproduce inside a living cell. The cell is then destroyed in the release of the new viruses. (Credit: Lumen Learning)

O’k, so if that’s the ‘life cycle’ of a virus, what are they physically? How do they manage to do what they do?

Well, physically viruses do have genetic material, which can either be in the form of DNA or RNA. All viruses will then have a shell of protein called a capsid surrounding the genetic material and protecting it. Additionally some viruses also have an envelope of fatty, lipid material around the proteins for further protection. That’s it, that’s all a virus consists of, and that’s why most viruses are so small, averaging only about 1/100th the size of a bacteria. In fact viruses are so small that the vast majority can only be seen with the high magnification possible in an electron microscope.

Typical structure of a virus. Not much here just DNA and a protective covering. (Credit: Florida State University)

Now if you’re wondering how did viruses ever evolve to become such complete parasites, how did anything that’s part alive and part not alive ever come into existence? Well you’re not the only one; microbiologists have been debating that question ever since the first virus was discovered back in the 1890s. Currently there are three leading ideas for where viruses came from.

The first idea is that viruses were once more normal cells, probably like bacteria, that became parasitic on other cells for their reproduction. There are in fact bacteria; chlamydia is one example, which can only reproduce inside a host cell. These proto-viruses then would have abandoned all other life functions in order to concentrate on reproduction. Again there are numerous examples of parasites that do this in nature. A tape worm for example has no digestive system, since it lives in your stomach you do its digesting for it. That way it can put more of its metabolism into reproduction. Perhaps viruses went even further, completely giving up metabolism of any kind outside of its host cell.

Tapeworms are common parasites among mammals, including humans. Living in our stomachs and intestines they have lost their own digestive systems in order to concentrate on reproduction. (Credit: Pinterest)

This idea has gotten a boost recently from a study led by Frank Aylward, Assistant Professor of Biological Science at Virginia Tech. Professor Aylward and his colleagues have been studying ‘Giant Viruses’, which are more then ten times the size of typical viruses. Carrying out a DNA analysis of the ‘Brown Tide Virus’ the researchers found genes directly related to metabolic processes, but why would organisms that don’t metabolize possess genes for metabolism?

Professor Aylward speculates that the virus uses the metabolic genes to better control the metabolism of the algae cells it infects. Still that leaves the question of where did a virus did metabolic genes from in the first place. One logical answer is that the metabolic genes were simply left over from the time when viruses were independent cells with a metabolism.

The second idea for a possible origin for viruses is that they evolved from ‘escaped’ bits of DNA or RNA outside of more normal cells. Such ‘Plasmids’ have been observed to move from one normal cell to another. Indeed single celled organisms like amoeba are occasionally known to exchange genetic material in this fashion. Perhaps some of these plasmids began to act for themselves, taking over the cell that absorbed them, becoming parasitic viruses in the process.

The final theory for the origin of viruses is simply that viruses evolved in parallel with normal living cells. The problem with this idea is that it’s logically difficult to understand how a proto-virus could use a proto-cell to make copies of itself if the proto-cell is still developing the processes needed to reproduce itself!

As life evolved from the primordial soup to high structured Eukaryota cells where did viruses break off and degenerate into parasites? (Credit: ViroBlogy)

All three of these hypotheses have some evidence in their favour, all three have big problems. Which will turn out to be true will only become clear when more evidence can be gathered.

By the way if you’re wondering, since viruses are so different from living cells, maybe not even alive, how can we kill them? Well, I don’t want to get into a philosophical argument over whether viruses die or are destroyed but fortunately soap and or alcohol will shatter that protein coating they have, exposing the fragile DNA that quickly breaks up. A good reminder to wash your hands often and use hand sanitizer!

Sage Advice! (Credit: Meme Generator)

Most people I suppose pretty much equate viruses with bacteria, after all they both cause diseases in human beings and that’s what we really care about. Most bacteria however are actually beneficial, they spend their lives breaking down dead and decaying organic matter into nutrients that other living things, mostly plants, can ingest. Only a few species of bacteria attack living cells and thereby cause disease.

False colour electronmicroscopic image of viruses attacking bacteria giving an idea of relative sizes. (Credit: Physics World)

Viruses on the other hand are purely destructive. They don’t do anything other than reproduce and that reproduction requires the death of a living cell. They are the ultimate parasite.